lytH [2017-8-11 16:0:3]

differentiation-associated peptidoglycan hydrolase involved in endospore cortex maturation

locus: BSU32340

pI: 6.89

mw: 39.48 kDa

protein length: 349 aa

gene length: 1047 bp

function: endospore cortex maturation

product: peptidoglycan hydrolase

essential: no

synonyms: yunA, yutA

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.4|Endopeptidases]
• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.5|Cell wall/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other]

Gene

Coordinates: 3,321,455 → 3,322,435

The protein

Catalyzed reaction/ biological activity

• cleaves the peptide bond between L-Ala (position 1 in the peptioglycan peptide) and D-Glu (position 2) [Pubmed|18266855]

Protein family

• peptidase M23B family (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|11AF08158121DEDFDDC0F64C52EFF3CF3AE30CE6|lytH]
  description: [Pubmed|12813075]

  sigma factors

  • [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK]: sigma factor, [Pubmed|12813075], in [regulon|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|SigK regulon]

  regulation

  • expressed late during sporulation in the mother cell ([protein|search|SigK]) [Pubmed|12813075]

Biological materials

Mutant

• MGNA-B579 (yunA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1578 NBRP B. subtilis, Japan]

References

Reviews

• 18266855

Original publications

• 12813075